[In Kabuki] In breakup plays, the woman coldly rejects the man she loves to secretly help him. [Today] To act cold toward someone; to lose patience or affection. *Note: 「愛想尽かし」は歌舞伎の演技用語だが、日常語「愛想を尽かす」が歌舞伎由来かは諸説あり